AustralieFrV1, Main, Exploration, bibRecord, 000F24

Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia

Identifieur interne : 000F24 ( Main/Exploration ); précédent : 000F23; suivant : 000F25

Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia

Auteurs : Michael R. Grever [États-Unis] ; Omar Abdel-Wahab [États-Unis] ; Leslie A. Andritsos [États-Unis] ; Versha Banerji [Canada] ; Jacqueline Barrientos [États-Unis] ; James S. Blachly [États-Unis] ; Timothy G. Call [États-Unis] ; Daniel Catovsky [Royaume-Uni] ; Claire Dearden [Royaume-Uni] ; Judit Demeter [Hongrie] ; Monica Else [Royaume-Uni] ; Francesco Forconi [Royaume-Uni] ; Alessandro Gozzetti [Italie] ; Anthony D. Ho [Allemagne] ; James B. Johnston [Canada] ; Jeffrey Jones [États-Unis] ; Gunnar Juliusson [Suède] ; Eric Kraut [États-Unis] ; Robert J. Kreitman [États-Unis] ; Loree Larratt [Canada] ; Francesco Lauria [Italie] ; Gerard Lozanski [États-Unis] ; Emili Montserrat [Espagne] ; Sameer A. Parikh [États-Unis] ; Jae H. Park [États-Unis] ; Aaron Polliack [Israël] ; Graeme R. Quest [Canada] ; Kanti R. Rai [États-Unis] ; Farhad Ravandi [États-Unis] ; Tadeusz Robak [Pologne] ; Alan Saven [États-Unis] ; John F. Seymour [Australie] ; Tamar Tadmor [Israël] ; Martin S. Tallman [États-Unis] ; Constantine Tam [Australie] ; Enrico Tiacci [Italie] ; Xavier Troussard [France] ; Clive S. Zent [États-Unis] ; Thorsten Zenz [Allemagne] ; Pier Luigi Zinzani [Italie] ; Brunangelo Falini [Italie]

Source :

Blood [ 0006-4971 ] ; 2017.

RBID : PMC:5290982

Descripteurs français

KwdFr :
- Antinéoplasiques (usage thérapeutique), Chloro-2 désoxyadénosine (usage thérapeutique), Humains, Leucémie à tricholeucocytes (diagnostic), Leucémie à tricholeucocytes (traitement médicamenteux), Maladie résiduelle (diagnostic), Maladie résiduelle (traitement médicamenteux), Pentostatine (usage thérapeutique), Prise en charge de la maladie, Récidive tumorale locale (diagnostic), Récidive tumorale locale (traitement médicamenteux), Résultat thérapeutique.
MESH :
- diagnostic : Leucémie à tricholeucocytes, Maladie résiduelle, Récidive tumorale locale.
- traitement médicamenteux : Leucémie à tricholeucocytes, Maladie résiduelle, Récidive tumorale locale.
- usage thérapeutique : Antinéoplasiques, Chloro-2 désoxyadénosine, Pentostatine.
- Humains, Prise en charge de la maladie, Résultat thérapeutique.

English descriptors

KwdEn :
- Antineoplastic Agents (therapeutic use), Cladribine (therapeutic use), Disease Management, Humans, Leukemia, Hairy Cell (diagnosis), Leukemia, Hairy Cell (drug therapy), Neoplasm Recurrence, Local (diagnosis), Neoplasm Recurrence, Local (drug therapy), Neoplasm, Residual (diagnosis), Neoplasm, Residual (drug therapy), Pentostatin (therapeutic use), Treatment Outcome.
MESH :
- chemical , therapeutic use : Antineoplastic Agents, Cladribine, Pentostatin.
- diagnosis : Leukemia, Hairy Cell, Neoplasm Recurrence, Local, Neoplasm, Residual.
- drug therapy : Leukemia, Hairy Cell, Neoplasm Recurrence, Local, Neoplasm, Residual.
- Disease Management, Humans, Treatment Outcome.

Abstract

Hairy cell leukemia is an uncommon hematologic malignancy characterized by pancytopenia and marked susceptibility to infection. Tremendous progress in the management of patients with this disease has resulted in high response rates and improved survival, yet relapse and an appropriate approach to re-treatment present continuing areas for research. The disease and its effective treatment are associated with immunosuppression. Because more patients are being treated with alternative programs, comparison of results will require general agreement on definitions of response, relapse, and methods of determining minimal residual disease. The development of internationally accepted, reproducible criteria is of paramount importance in evaluating and comparing clinical trials to provide optimal care. Despite the success achieved in managing these patients, continued participation in available clinical trials in the first-line and particularly in the relapse setting is highly recommended. The Hairy Cell Leukemia Foundation convened an international conference to provide common definitions and structure to guide current management. There is substantial opportunity for continued research in this disease. In addition to the importance of optimizing the prevention and management of the serious risk of infection, organized evaluations of minimal residual disease and treatment at relapse offer ample opportunities for clinical research. Finally, a scholarly evaluation of quality of life in the increasing number of survivors of this now manageable chronic illness merits further study. The development of consensus guidelines for this disease offers a framework for continued enhancement of the outcome for patients.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290982

DOI: 10.1182/blood-2016-01-689422
PubMed: 27903528
PubMed Central: 5290982

Affiliations:

Allemagne, Australie, Canada, Espagne, France, Hongrie, Israël, Italie, Pologne, Royaume-Uni, Suède, États-Unis
Angleterre, Bade-Wurtemberg, Basse-Normandie, Californie, Catalogne, District de Karlsruhe, Grand Londres, Hongrie centrale, Manitoba, Maryland, Minnesota, Ohio, Région Normandie, Texas, Victoria (État), État de New York
Barcelone, Budapest, Caen, Heidelberg, Londres, Melbourne, Winnipeg
Université de Melbourne, Université du Manitoba

Le document en format XML

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<author><name sortKey="Ho, Anthony D" sort="Ho, Anthony D" uniqKey="Ho A" first="Anthony D." last="Ho">Anthony D. Ho</name>
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<author><name sortKey="Jones, Jeffrey" sort="Jones, Jeffrey" uniqKey="Jones J" first="Jeffrey" last="Jones">Jeffrey Jones</name>
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<author><name sortKey="Larratt, Loree" sort="Larratt, Loree" uniqKey="Larratt L" first="Loree" last="Larratt">Loree Larratt</name>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine, University of Alberta, Edmonton, AB</wicri:regionArea>
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<author><name sortKey="Lauria, Francesco" sort="Lauria, Francesco" uniqKey="Lauria F" first="Francesco" last="Lauria">Francesco Lauria</name>
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<author><name sortKey="Lozanski, Gerard" sort="Lozanski, Gerard" uniqKey="Lozanski G" first="Gerard" last="Lozanski">Gerard Lozanski</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
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<wicri:cityArea>Department of Pathology, The Ohio State University, Columbus</wicri:cityArea>
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<author><name sortKey="Montserrat, Emili" sort="Montserrat, Emili" uniqKey="Montserrat E" first="Emili" last="Montserrat">Emili Montserrat</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Hematology, Hospital Clinic, University of Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
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<author><name sortKey="Parikh, Sameer A" sort="Parikh, Sameer A" uniqKey="Parikh S" first="Sameer A." last="Parikh">Sameer A. Parikh</name>
<affiliation wicri:level="2"><nlm:aff id="aff5">Division of Hematology, Mayo Clinic, Rochester, MN;</nlm:aff>
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<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Hematology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
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<author><name sortKey="Park, Jae H" sort="Park, Jae H" uniqKey="Park J" first="Jae H." last="Park">Jae H. Park</name>
<affiliation wicri:level="2"><nlm:aff id="aff2">Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
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<wicri:cityArea>Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea>
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</author>
<author><name sortKey="Polliack, Aaron" sort="Polliack, Aaron" uniqKey="Polliack A" first="Aaron" last="Polliack">Aaron Polliack</name>
<affiliation wicri:level="1"><nlm:aff id="aff17">Department of Hematology, Hadassah University Hospital and Hebrew University Medical School, Jerusalem, Israel;</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Hematology, Hadassah University Hospital and Hebrew University Medical School, Jerusalem</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Quest, Graeme R" sort="Quest, Graeme R" uniqKey="Quest G" first="Graeme R." last="Quest">Graeme R. Quest</name>
<affiliation wicri:level="1"><nlm:aff id="aff18">Department of Laboratory Medicine and Pathology, University Health Network, Toronto, ON, Canada;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Laboratory Medicine and Pathology, University Health Network, Toronto, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
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</author>
<author><name sortKey="Rai, Kanti R" sort="Rai, Kanti R" uniqKey="Rai K" first="Kanti R." last="Rai">Kanti R. Rai</name>
<affiliation wicri:level="2"><nlm:aff id="aff4">Department of Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, Hofstra University, Hempstead, NY;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
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<wicri:cityArea>Department of Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, Hofstra University, Hempstead</wicri:cityArea>
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</author>
<author><name sortKey="Ravandi, Farhad" sort="Ravandi, Farhad" uniqKey="Ravandi F" first="Farhad" last="Ravandi">Farhad Ravandi</name>
<affiliation wicri:level="2"><nlm:aff id="aff19">Section of Developmental Therapeutics, Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Section of Developmental Therapeutics, Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea>
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<author><name sortKey="Robak, Tadeusz" sort="Robak, Tadeusz" uniqKey="Robak T" first="Tadeusz" last="Robak">Tadeusz Robak</name>
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<wicri:regionArea>Department of Hematology, Medical University of Lodz, Lodz</wicri:regionArea>
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<author><name sortKey="Saven, Alan" sort="Saven, Alan" uniqKey="Saven A" first="Alan" last="Saven">Alan Saven</name>
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<author><name sortKey="Seymour, John F" sort="Seymour, John F" uniqKey="Seymour J" first="John F." last="Seymour">John F. Seymour</name>
<affiliation wicri:level="4"><nlm:aff id="aff22">Haematology Department, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC, Australia;</nlm:aff>
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<author><name sortKey="Tadmor, Tamar" sort="Tadmor, Tamar" uniqKey="Tadmor T" first="Tamar" last="Tadmor">Tamar Tadmor</name>
<affiliation wicri:level="1"><nlm:aff id="aff23">Hematology Unit, Bnai-Zion Medical Center, and the Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, Israel;</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Hematology Unit, Bnai-Zion Medical Center, and the Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa</wicri:regionArea>
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</author>
<author><name sortKey="Tallman, Martin S" sort="Tallman, Martin S" uniqKey="Tallman M" first="Martin S." last="Tallman">Martin S. Tallman</name>
<affiliation wicri:level="2"><nlm:aff id="aff2">Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
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</affiliation>
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<author><name sortKey="Tam, Constantine" sort="Tam, Constantine" uniqKey="Tam C" first="Constantine" last="Tam">Constantine Tam</name>
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</placeName>
</affiliation>
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<author><name sortKey="Tiacci, Enrico" sort="Tiacci, Enrico" uniqKey="Tiacci E" first="Enrico" last="Tiacci">Enrico Tiacci</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Hematology, Department of Medicine, University and Hospital of Perugia, Perugia</wicri:regionArea>
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<author><name sortKey="Troussard, Xavier" sort="Troussard, Xavier" uniqKey="Troussard X" first="Xavier" last="Troussard">Xavier Troussard</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Hematology, Centre Hospitalier Universitaire Côte de Nacre, Caen</wicri:regionArea>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zent, Clive S" sort="Zent, Clive S" uniqKey="Zent C" first="Clive S." last="Zent">Clive S. Zent</name>
<affiliation wicri:level="2"><nlm:aff id="aff26">James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zenz, Thorsten" sort="Zenz, Thorsten" uniqKey="Zenz T" first="Thorsten" last="Zenz">Thorsten Zenz</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Molecular Therapy in Hematology and Oncology, National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zinzani, Pier Luigi" sort="Zinzani, Pier Luigi" uniqKey="Zinzani P" first="Pier Luigi" last="Zinzani">Pier Luigi Zinzani</name>
<affiliation wicri:level="1"><nlm:aff id="aff28">Institute of Hematology “Seràgnoli,” University of Bologna, Bologna, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Hematology “Seràgnoli,” University of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Falini, Brunangelo" sort="Falini, Brunangelo" uniqKey="Falini B" first="Brunangelo" last="Falini">Brunangelo Falini</name>
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<country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Hematology, Department of Medicine, University and Hospital of Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia</title>
<author><name sortKey="Grever, Michael R" sort="Grever, Michael R" uniqKey="Grever M" first="Michael R." last="Grever">Michael R. Grever</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Division of Hematology, Department of Internal Medicine, The Ohio State University James Cancer Hospital, Columbus, OH;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Division of Hematology, Department of Internal Medicine, The Ohio State University James Cancer Hospital, Columbus</wicri:cityArea>
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<author><name sortKey="Abdel Wahab, Omar" sort="Abdel Wahab, Omar" uniqKey="Abdel Wahab O" first="Omar" last="Abdel-Wahab">Omar Abdel-Wahab</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
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<wicri:cityArea>Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea>
</affiliation>
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<author><name sortKey="Andritsos, Leslie A" sort="Andritsos, Leslie A" uniqKey="Andritsos L" first="Leslie A." last="Andritsos">Leslie A. Andritsos</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Division of Hematology, Department of Internal Medicine, The Ohio State University James Cancer Hospital, Columbus, OH;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Division of Hematology, Department of Internal Medicine, The Ohio State University James Cancer Hospital, Columbus</wicri:cityArea>
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</author>
<author><name sortKey="Banerji, Versha" sort="Banerji, Versha" uniqKey="Banerji V" first="Versha" last="Banerji">Versha Banerji</name>
<affiliation wicri:level="4"><nlm:aff id="aff3">Section of Hematology/Oncology, University of Manitoba, Winnipeg, MB, Canada;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Section of Hematology/Oncology, University of Manitoba, Winnipeg, MB</wicri:regionArea>
<orgName type="university">Université du Manitoba</orgName>
<placeName><settlement type="city">Winnipeg</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Barrientos, Jacqueline" sort="Barrientos, Jacqueline" uniqKey="Barrientos J" first="Jacqueline" last="Barrientos">Jacqueline Barrientos</name>
<affiliation wicri:level="2"><nlm:aff id="aff4">Department of Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, Hofstra University, Hempstead, NY;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, Hofstra University, Hempstead</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Blachly, James S" sort="Blachly, James S" uniqKey="Blachly J" first="James S." last="Blachly">James S. Blachly</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Division of Hematology, Department of Internal Medicine, The Ohio State University James Cancer Hospital, Columbus, OH;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Division of Hematology, Department of Internal Medicine, The Ohio State University James Cancer Hospital, Columbus</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Call, Timothy G" sort="Call, Timothy G" uniqKey="Call T" first="Timothy G." last="Call">Timothy G. Call</name>
<affiliation wicri:level="2"><nlm:aff id="aff5">Division of Hematology, Mayo Clinic, Rochester, MN;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Hematology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Catovsky, Daniel" sort="Catovsky, Daniel" uniqKey="Catovsky D" first="Daniel" last="Catovsky">Daniel Catovsky</name>
<affiliation wicri:level="3"><nlm:aff id="aff6">Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Molecular Pathology, The Institute of Cancer Research, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dearden, Claire" sort="Dearden, Claire" uniqKey="Dearden C" first="Claire" last="Dearden">Claire Dearden</name>
<affiliation wicri:level="3"><nlm:aff id="aff7">Department of Haemato-Oncology, Royal Marsden Biomedical Research Centre, London, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Haemato-Oncology, Royal Marsden Biomedical Research Centre, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Demeter, Judit" sort="Demeter, Judit" uniqKey="Demeter J" first="Judit" last="Demeter">Judit Demeter</name>
<affiliation wicri:level="3"><nlm:aff id="aff8">First Department of Internal Medicine, Semmelweis University, Budapest, Hungary;</nlm:aff>
<country xml:lang="fr">Hongrie</country>
<wicri:regionArea>First Department of Internal Medicine, Semmelweis University, Budapest</wicri:regionArea>
<placeName><settlement type="city">Budapest</settlement>
<region nuts="2">Hongrie centrale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Else, Monica" sort="Else, Monica" uniqKey="Else M" first="Monica" last="Else">Monica Else</name>
<affiliation wicri:level="3"><nlm:aff id="aff6">Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Molecular Pathology, The Institute of Cancer Research, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Forconi, Francesco" sort="Forconi, Francesco" uniqKey="Forconi F" first="Francesco" last="Forconi">Francesco Forconi</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Haematology Department, University Hospital Trust and Cancer Sciences Unit, Cancer Research UK and National Institute for Health Research Experimental Cancer Medicine Centres, Faculty of Medicine, University of Southampton, Southampton, United Kingdom;</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Haematology Department, University Hospital Trust and Cancer Sciences Unit, Cancer Research UK and National Institute for Health Research Experimental Cancer Medicine Centres, Faculty of Medicine, University of Southampton, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gozzetti, Alessandro" sort="Gozzetti, Alessandro" uniqKey="Gozzetti A" first="Alessandro" last="Gozzetti">Alessandro Gozzetti</name>
<affiliation wicri:level="1"><nlm:aff id="aff10">Hematology, Azienda Ospedaliera Universitaria Senese, Siena, Italy;</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Hematology, Azienda Ospedaliera Universitaria Senese, Siena</wicri:regionArea>
<wicri:noRegion>Siena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ho, Anthony D" sort="Ho, Anthony D" uniqKey="Ho A" first="Anthony D." last="Ho">Anthony D. Ho</name>
<affiliation wicri:level="3"><nlm:aff id="aff11">Department of Medicine V, University of Heidelberg, Heidelberg, Germany;</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medicine V, University of Heidelberg, Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johnston, James B" sort="Johnston, James B" uniqKey="Johnston J" first="James B." last="Johnston">James B. Johnston</name>
<affiliation wicri:level="4"><nlm:aff id="aff3">Section of Hematology/Oncology, University of Manitoba, Winnipeg, MB, Canada;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Section of Hematology/Oncology, University of Manitoba, Winnipeg, MB</wicri:regionArea>
<orgName type="university">Université du Manitoba</orgName>
<placeName><settlement type="city">Winnipeg</settlement>
<region type="state">Manitoba</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jones, Jeffrey" sort="Jones, Jeffrey" uniqKey="Jones J" first="Jeffrey" last="Jones">Jeffrey Jones</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Division of Hematology, Department of Internal Medicine, The Ohio State University James Cancer Hospital, Columbus, OH;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Division of Hematology, Department of Internal Medicine, The Ohio State University James Cancer Hospital, Columbus</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Juliusson, Gunnar" sort="Juliusson, Gunnar" uniqKey="Juliusson G" first="Gunnar" last="Juliusson">Gunnar Juliusson</name>
<affiliation wicri:level="1"><nlm:aff id="aff12">Department of Hematology, Skåne University Hospital and Stem Cell Center, Lund University, Lund, Sweden;</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Hematology, Skåne University Hospital and Stem Cell Center, Lund University, Lund</wicri:regionArea>
<wicri:noRegion>Lund</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kraut, Eric" sort="Kraut, Eric" uniqKey="Kraut E" first="Eric" last="Kraut">Eric Kraut</name>
<affiliation wicri:level="2"><nlm:aff id="aff1">Division of Hematology, Department of Internal Medicine, The Ohio State University James Cancer Hospital, Columbus, OH;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Division of Hematology, Department of Internal Medicine, The Ohio State University James Cancer Hospital, Columbus</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kreitman, Robert J" sort="Kreitman, Robert J" uniqKey="Kreitman R" first="Robert J." last="Kreitman">Robert J. Kreitman</name>
<affiliation wicri:level="2"><nlm:aff id="aff13">Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Larratt, Loree" sort="Larratt, Loree" uniqKey="Larratt L" first="Loree" last="Larratt">Loree Larratt</name>
<affiliation wicri:level="1"><nlm:aff id="aff14">Department of Medicine, University of Alberta, Edmonton, AB, Canada;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine, University of Alberta, Edmonton, AB</wicri:regionArea>
<wicri:noRegion>AB</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lauria, Francesco" sort="Lauria, Francesco" uniqKey="Lauria F" first="Francesco" last="Lauria">Francesco Lauria</name>
<affiliation wicri:level="1"><nlm:aff id="aff10">Hematology, Azienda Ospedaliera Universitaria Senese, Siena, Italy;</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Hematology, Azienda Ospedaliera Universitaria Senese, Siena</wicri:regionArea>
<wicri:noRegion>Siena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lozanski, Gerard" sort="Lozanski, Gerard" uniqKey="Lozanski G" first="Gerard" last="Lozanski">Gerard Lozanski</name>
<affiliation wicri:level="2"><nlm:aff id="aff15">Department of Pathology, The Ohio State University, Columbus, OH;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Department of Pathology, The Ohio State University, Columbus</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Montserrat, Emili" sort="Montserrat, Emili" uniqKey="Montserrat E" first="Emili" last="Montserrat">Emili Montserrat</name>
<affiliation wicri:level="3"><nlm:aff id="aff16">Department of Hematology, Hospital Clinic, University of Barcelona, Barcelona, Spain;</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Hematology, Hospital Clinic, University of Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Parikh, Sameer A" sort="Parikh, Sameer A" uniqKey="Parikh S" first="Sameer A." last="Parikh">Sameer A. Parikh</name>
<affiliation wicri:level="2"><nlm:aff id="aff5">Division of Hematology, Mayo Clinic, Rochester, MN;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Hematology, Mayo Clinic, Rochester</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Park, Jae H" sort="Park, Jae H" uniqKey="Park J" first="Jae H." last="Park">Jae H. Park</name>
<affiliation wicri:level="2"><nlm:aff id="aff2">Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Polliack, Aaron" sort="Polliack, Aaron" uniqKey="Polliack A" first="Aaron" last="Polliack">Aaron Polliack</name>
<affiliation wicri:level="1"><nlm:aff id="aff17">Department of Hematology, Hadassah University Hospital and Hebrew University Medical School, Jerusalem, Israel;</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Hematology, Hadassah University Hospital and Hebrew University Medical School, Jerusalem</wicri:regionArea>
<wicri:noRegion>Jerusalem</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Quest, Graeme R" sort="Quest, Graeme R" uniqKey="Quest G" first="Graeme R." last="Quest">Graeme R. Quest</name>
<affiliation wicri:level="1"><nlm:aff id="aff18">Department of Laboratory Medicine and Pathology, University Health Network, Toronto, ON, Canada;</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Laboratory Medicine and Pathology, University Health Network, Toronto, ON</wicri:regionArea>
<wicri:noRegion>ON</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rai, Kanti R" sort="Rai, Kanti R" uniqKey="Rai K" first="Kanti R." last="Rai">Kanti R. Rai</name>
<affiliation wicri:level="2"><nlm:aff id="aff4">Department of Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, Hofstra University, Hempstead, NY;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Medicine, Hofstra North Shore-Long Island Jewish School of Medicine, Hofstra University, Hempstead</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ravandi, Farhad" sort="Ravandi, Farhad" uniqKey="Ravandi F" first="Farhad" last="Ravandi">Farhad Ravandi</name>
<affiliation wicri:level="2"><nlm:aff id="aff19">Section of Developmental Therapeutics, Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Section of Developmental Therapeutics, Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Robak, Tadeusz" sort="Robak, Tadeusz" uniqKey="Robak T" first="Tadeusz" last="Robak">Tadeusz Robak</name>
<affiliation wicri:level="1"><nlm:aff id="aff20">Department of Hematology, Medical University of Lodz, Lodz, Poland;</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Hematology, Medical University of Lodz, Lodz</wicri:regionArea>
<wicri:noRegion>Lodz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Saven, Alan" sort="Saven, Alan" uniqKey="Saven A" first="Alan" last="Saven">Alan Saven</name>
<affiliation wicri:level="2"><nlm:aff id="aff21">Division of Hematology and Oncology, Scripps Clinic, La Jolla, CA;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Hematology and Oncology, Scripps Clinic, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Seymour, John F" sort="Seymour, John F" uniqKey="Seymour J" first="John F." last="Seymour">John F. Seymour</name>
<affiliation wicri:level="4"><nlm:aff id="aff22">Haematology Department, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC, Australia;</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Haematology Department, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tadmor, Tamar" sort="Tadmor, Tamar" uniqKey="Tadmor T" first="Tamar" last="Tadmor">Tamar Tadmor</name>
<affiliation wicri:level="1"><nlm:aff id="aff23">Hematology Unit, Bnai-Zion Medical Center, and the Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, Israel;</nlm:aff>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Hematology Unit, Bnai-Zion Medical Center, and the Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa</wicri:regionArea>
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<author><name sortKey="Tallman, Martin S" sort="Tallman, Martin S" uniqKey="Tallman M" first="Martin S." last="Tallman">Martin S. Tallman</name>
<affiliation wicri:level="2"><nlm:aff id="aff2">Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Tam, Constantine" sort="Tam, Constantine" uniqKey="Tam C" first="Constantine" last="Tam">Constantine Tam</name>
<affiliation wicri:level="4"><nlm:aff id="aff22">Haematology Department, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC, Australia;</nlm:aff>
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<author><name sortKey="Tiacci, Enrico" sort="Tiacci, Enrico" uniqKey="Tiacci E" first="Enrico" last="Tiacci">Enrico Tiacci</name>
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<affiliation wicri:level="3"><nlm:aff id="aff25">Department of Hematology, Centre Hospitalier Universitaire Côte de Nacre, Caen, France;</nlm:aff>
<country xml:lang="fr">France</country>
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<placeName><region type="region">Région Normandie</region>
<region type="old region">Basse-Normandie</region>
<settlement type="city">Caen</settlement>
</placeName>
</affiliation>
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<author><name sortKey="Zent, Clive S" sort="Zent, Clive S" uniqKey="Zent C" first="Clive S." last="Zent">Clive S. Zent</name>
<affiliation wicri:level="2"><nlm:aff id="aff26">James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY;</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester</wicri:cityArea>
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<author><name sortKey="Zenz, Thorsten" sort="Zenz, Thorsten" uniqKey="Zenz T" first="Thorsten" last="Zenz">Thorsten Zenz</name>
<affiliation wicri:level="3"><nlm:aff wicri:cut="; and" id="aff27">Department of Molecular Therapy in Hematology and Oncology, National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Molecular Therapy in Hematology and Oncology, National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zinzani, Pier Luigi" sort="Zinzani, Pier Luigi" uniqKey="Zinzani P" first="Pier Luigi" last="Zinzani">Pier Luigi Zinzani</name>
<affiliation wicri:level="1"><nlm:aff id="aff28">Institute of Hematology “Seràgnoli,” University of Bologna, Bologna, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Hematology “Seràgnoli,” University of Bologna, Bologna</wicri:regionArea>
<wicri:noRegion>Bologna</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Falini, Brunangelo" sort="Falini, Brunangelo" uniqKey="Falini B" first="Brunangelo" last="Falini">Brunangelo Falini</name>
<affiliation wicri:level="1"><nlm:aff id="aff24">Institute of Hematology, Department of Medicine, University and Hospital of Perugia, Perugia, Italy;</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Institute of Hematology, Department of Medicine, University and Hospital of Perugia, Perugia</wicri:regionArea>
<wicri:noRegion>Perugia</wicri:noRegion>
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<series><title level="j">Blood</title>
<idno type="ISSN">0006-4971</idno>
<idno type="eISSN">1528-0020</idno>
<imprint><date when="2017">2017</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic Agents (therapeutic use)</term>
<term>Cladribine (therapeutic use)</term>
<term>Disease Management</term>
<term>Humans</term>
<term>Leukemia, Hairy Cell (diagnosis)</term>
<term>Leukemia, Hairy Cell (drug therapy)</term>
<term>Neoplasm Recurrence, Local (diagnosis)</term>
<term>Neoplasm Recurrence, Local (drug therapy)</term>
<term>Neoplasm, Residual (diagnosis)</term>
<term>Neoplasm, Residual (drug therapy)</term>
<term>Pentostatin (therapeutic use)</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Antinéoplasiques (usage thérapeutique)</term>
<term>Chloro-2 désoxyadénosine (usage thérapeutique)</term>
<term>Humains</term>
<term>Leucémie à tricholeucocytes (diagnostic)</term>
<term>Leucémie à tricholeucocytes (traitement médicamenteux)</term>
<term>Maladie résiduelle (diagnostic)</term>
<term>Maladie résiduelle (traitement médicamenteux)</term>
<term>Pentostatine (usage thérapeutique)</term>
<term>Prise en charge de la maladie</term>
<term>Récidive tumorale locale (diagnostic)</term>
<term>Récidive tumorale locale (traitement médicamenteux)</term>
<term>Résultat thérapeutique</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antineoplastic Agents</term>
<term>Cladribine</term>
<term>Pentostatin</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Leukemia, Hairy Cell</term>
<term>Neoplasm Recurrence, Local</term>
<term>Neoplasm, Residual</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Leucémie à tricholeucocytes</term>
<term>Maladie résiduelle</term>
<term>Récidive tumorale locale</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Leukemia, Hairy Cell</term>
<term>Neoplasm Recurrence, Local</term>
<term>Neoplasm, Residual</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Leucémie à tricholeucocytes</term>
<term>Maladie résiduelle</term>
<term>Récidive tumorale locale</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antinéoplasiques</term>
<term>Chloro-2 désoxyadénosine</term>
<term>Pentostatine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Disease Management</term>
<term>Humans</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Humains</term>
<term>Prise en charge de la maladie</term>
<term>Résultat thérapeutique</term>
</keywords>
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<front><div type="abstract" xml:lang="en"><p>Hairy cell leukemia is an uncommon hematologic malignancy characterized by pancytopenia and marked susceptibility to infection. Tremendous progress in the management of patients with this disease has resulted in high response rates and improved survival, yet relapse and an appropriate approach to re-treatment present continuing areas for research. The disease and its effective treatment are associated with immunosuppression. Because more patients are being treated with alternative programs, comparison of results will require general agreement on definitions of response, relapse, and methods of determining minimal residual disease. The development of internationally accepted, reproducible criteria is of paramount importance in evaluating and comparing clinical trials to provide optimal care. Despite the success achieved in managing these patients, continued participation in available clinical trials in the first-line and particularly in the relapse setting is highly recommended. The Hairy Cell Leukemia Foundation convened an international conference to provide common definitions and structure to guide current management. There is substantial opportunity for continued research in this disease. In addition to the importance of optimizing the prevention and management of the serious risk of infection, organized evaluations of minimal residual disease and treatment at relapse offer ample opportunities for clinical research. Finally, a scholarly evaluation of quality of life in the increasing number of survivors of this now manageable chronic illness merits further study. The development of consensus guidelines for this disease offers a framework for continued enhancement of the outcome for patients.</p>
</div>
</front>
</TEI>
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Serveur d'exploration sur les relations entre la France et l'Australie

Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia

Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia

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